Laboratory of Cancer Treatment and Tissue Regeneration

About us

Our laboratory is concerned on study of regeneration of parenchymal organs in a relation to supposed extensive surgical procedures. Our goal is to experimentally verify all possibilities that can be used for the treatment of patients with cancers, especially liver malignancies. We are checking the significance of stimulated regeneration of the future liver remnant damaged for example by oncologic experimental treatment in large animals (established are experimental model of steatohepatitis associated with chemotherapy, model of toxic alcoholic liver disease, model of biliary cirrhosis etc.)

We also develop special software models and advanced imaging analysis to predict regeneration capacity of the liver parenchyma and diagnose focal and diffuse liver diseases.

There is also included imaging of a portal system microcirculation as well. Finally we use our findings to spread our clinical treatment possibilities. We closely cooperate with the Labs of Pharmacogenomics, Tumor Biology and Quantitative Histology and we try to transfer their research results to our clinical requirements and applications.

Our team is fully instrumentally equipped to perform experiments in large animals. We also have skilled team of experts (including surgeons, anaesthesiologists, radiologists, biomechanics or experts of theoretical and laboratory fields) available to perform broad spectrum of surgical procedures. This team participates every year in preparing of the Summer School of Experimental Surgery annually held by our medical school.

Long-term aims

  • regeneration of liver parenchyma and liver surgery
  • portal micro- and macrocirculation
  • reconstruction of portal system
  • surgical and oncological treatment of malignancies
  • immune system behaviour during progression of tumour disease

Releated Research themes

Contact

Biomedical Center
alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí

Members

  • Václav Liška, M.D., Ph.D. – Research Group Leader
  • Hynek Mírka, M.D., Ph.D.
  • Prof. Boris Kreuzberg, M.D., Ph.D.
  • Assoc. Prof. Luboš Holubec, M.D., Ph.D.
  • Lenka Haidingerová, M.D.
  • Marie Karlíková, Ph.D., M.Sc.
  • Vladislava Mlejnková, M.Sc.
  • Ondřej Vyčítal, M.D.
  • Jan Brůha, M.D.
  • Ondřej Fiala, M.D.
  • Miroslav Svobodová, Ph.D., M.Sc.
  • Petr Hošek, M.Sc. (also Laboratory of Tumor Biology)
  • Miroslav Jiřík, M.Sc.
  • Lada Eberlová, M.D., Ph.D.
  • Richard Pálek
  • Martin Skála

Publications and Patents

News

Contact

Charles Univerzity
Faculty of Medicine in Pilsen
Biomedical Center

alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí

T: +420 377 593 810
E: This email address is being protected from spambots. You need JavaScript enabled to view it.

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