Investigated projects and grants

• IRP 2016–2018 6059/0400 – International Summer school of experimental surgery.
• 2017–2018 project GAUK 1206417 – Morphology variability and quantitative distribution of fibrotic tissue in porcine liver. IRP 2016–2018 – Educational and research progress of microanatomy of parenchymatous organs.
• 2016–2018 European project Eramsus+ - MedTrain3DModsim – Novel educational materials in medical training with 3D modeling applications and simulation modalities (Virtual reality and augmented reality).
• 2017 project SVV 260392/2017: Microanatomical models of liver parenchyma perfusion and in vitro models of chosen mesenchymal and epithelial cells in patologic conditions as source of information for prediction of liver regeneration capacity.
• 2016 – project SVV 260284/2016: Study of vascular changes during aging and importance of perfusion in liver regeneration.

Publications

2016

1. Mirka H., Ferda J., Baxa J.: Assessment of myocardial enhancement during coronary CT angiography in critically ill patients. European Journal of Radiology, 85, 2016:1909-1913. DOI: 10.1016/j.ejrad.2016.07.004
2. Jirik M., Tonar Z., Kralickova A., Eberlova L., Mirka H., Kochova P., Gregor T., Hosek P., Svobodova M., Rohan E., Kralickova M., Liska V.: Stereological quantification of microvessels using semiautomated evaluation of X-ray microtomography of hepatic vascular corrosion casts. International Journal of Computer Assisted Radiology and Surgery, 11, 2016:1803-1819. DOI: 10.1007/s11548-016-1378-3
3. Vychytilova-Faltejskova P., Pesta M., Radova L., Liska V., Daum O., Kala Z., Svoboda M., Kiss I., Slaby O.: Genome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer. Cancer Genomics and Proteomics, 13, 2016:311-316.
4. Vymetalkova V., Vodicka P., Pardini B., Rosa F., Levy M., Schneiderova M., Liska V., Vodickova L., Nilsson T., Farkas S.: Epigenome-wide analysis of DNA methylation reveals a rectal cancer-specific epigenomic signature. Epigenomics, 8, 2016:1193-1207. DOI: 10.2217/epi-2016-0044
5. Korenkova V., Slyskova J., Novosadova V., Pizzamiglio S., Langerova L., Bjorkman J., Vycital O., Liska V., Levy M., Veskrna K., Vodicka P., Vodickova L., Kubista M., Verderio P.: The focus on sample quality: Influence of colon tissue collection on reliability of qPCR data. Scientific Reports, 6, 2016. DOI: 10.1038/srep29023
6. Kunicka T., Prochazka P., Krus I., Bendova P., Protivova M., Susova S., Hlavac V., Liska V., Novak P., Schneiderova M., Pitule P., Bruha J., Vycital O., Vodicka P., Soucek P.: Molecular profile of 5-fluorouracil pathway genes in colorectal carcinoma. BMC Cancer, 16, 2016. DOI: 10.1186/s12885-016-2826-8
7. Holubec L., Polivka J., Safanda M., Karas M., Liska V.: The Role of Cetuximab in the Induction of Anticancer Immune Response in Colorectal Cancer Treatment. Anticancer Research, 36, 2016:4421-4426. DOI: 10.21873/anticanres.10985
8. Ruszniewski P., Valle JW., Lombard-Bohas C., Cuthbertson DJ., Perros P., Holubec L., Delle Fave G., Smith D., Niccoli P., Maisonobe P., Atlan P., Caplin ME.: Patient-reported outcomes with lanreotide Autogel/Depot for carcinoid syndrome: An international observational study. Digestive and Liver Disease, 48, 2016:552-558. DOI: 10.1016/j.dld.2015.12.013
9. Karas M., Steinerova K., Lysak D., Hrabetova M., Jungova A., Sramek J., Jindra P., Polivka J., Holubec L.: Pre-transplant Quantitative Determination of NPM1 Mutation Significantly Predicts Outcome of AIlogeneic Hematopoietic Stem Cell Transplantation in Patients with Normal Karyotype AML in Complete Remission. Anticancer Research, 36, 2016:5487-5498. DOI: 10.21873/anticanres.11130
10. Eberlova L., Liska V., Mirka H., Gregor T., Tonar Z., Palek R., Skala M., Bruha J., Vycital O., Kalusova K., Haviar S., Kralickova M., Lametschwandtner A.: Porcine Liver Vascular Bed in Biodur E20 Corrosion Casts. Folia Morphologica, 75, 2016:154-161. DOI: 10.5603/FM.a2015.0094
11. Fiala O., Büchler T., Mohelnikova-Duchonova B., Melichar , Matejka VM., Holubec L., Kulhankova J., Bortlicek Z., Bartouskova M., Liska V., Topolcan O., Sedivcova M., Finek J.: G12V and G12A KRAS mutations are associated with poor outcome in patients with metastatic colorectal cancer treated with bevacizumab. Tumor Biology, 37, 2016:6823-6830. DOI: 10.1007/s13277-015-4523-7
12. Slouka D., Polenik P., Hes O., Smid D., Slama K., Hosek P., Boudova L.: Can we improve clinical results of tonsillectomy using lasers?. Journal of Applied Biomedicine, 2016, 2016:35-40. DOI: 10.1016/j.jab.2015.08.002
13. Fiala O., Pesek M., Finek J., Svaton M., Minarik M., Benesova L., Bortlicek Z., Kucera R., Topolcan O.: Pemetrexed Versus Erlotinib in the Second-line Treatment of Patients with Advanced-stage Non-squamous NSCLC Harboring Wild-type EGFR Gene. Anticancer Research, 36, 2016:447-453.
14. Fiala O., Pesek M., Finek J., Svaton M., Sorejs O., Bortlicek Z., Kucera R., Topolcan O.: Prognostic Significance of Serum Tumor Markers in Patients with Advanced-stage NSCLC Treated with Pemetrexed-based Chemotherapy. Anticancer Research, 36, 2016:461-466.
15. Fiala O., Pesek M., Finek J., Minarik M., Benesova L., Sorejs O., Svaton M., Bortlicek Z., Kucera R., Topolcan O.: Epidermal Growth Factor Receptor Gene Amplification in Patients with Advanced-stage NSCLC. Anticancer Research, 36, 2016:455-460.
16. Kucera R., Topolcan O., Fiala O., Kinkorova J., Treska V., Zednikova I., Slouka D., Simanek V., Safanda M., Babuska V.: The Role of TPS and TPA in the Diagnostics of Distant Metastases. Anticancer Research, 36, 2016:773-777.
17. Svaton M., Fiala O., Pesek M., Bortlicek Z., Minarik M., Benesova L., Topolcan O.: The Prognostic Role of KRAS Mutation in Patients with Advanced NSCLC Treated with Second- or Third-line Chemotherapy. Anticancer Research, 36, 2016:1077-1082.
18. Kucera R., Smid D., Topolcan O., Karlikova M., Fiala O., Slouka D., Skalicky T., Treska V., Kulda V., Simanek V., Safanda M., Pesta M.: Searching for New Biomarkers and the Use of Multivariate Analysis in Gastric Cancer Diagnostics. Anticancer Research, 36, 2016:1967-1971.
19. Fiala O., Pesek M., Finek J., Topolcan O., Racek J., Svaton M., Kucera R., Minarik M., Benesova L., Bortlicek Z., Chloupkova R., Poprach A., Büchler T.: Change in Serum Lactate Dehydrogenase Is Associated with Outcome of Patients with Advanced-stage NSCLC Treated with Erlotinib. Anticancer Research, 36, 2016:2459-2465.
20. Windrichova J., Fuchsova R., Kucera R., Topolcan O., Fiala O., Finek J., Slipkova D., Karlikova M., Svobodova J.: Testing of a Novel Cancer Metastatic Multiplex Panel for the Detection of Bone-metastatic Disease - a Pilot Study. Anticancer Research, 36, 2016:1973-1978.
21. Fiala O., Pesek M., Finek J., Racek J., Minarik M., Benesova L., Bortlicek Z., Sorejs O., Kucera R., Topolcan O.: Serum albumin is a strong predictor of survival in patients with advanced-stage non-small cell lung cancer treated with erlotinib. Neoplasma, 63, 2016:471-476. DOI: 10.4149/318_151001N512
22. Krizkova V., Dubova M., Susova S., Vycital O., Bruha J., Skala M., Liska V., Daum O., Soucek P.: Protein expression of ATP-binding cassette transporters ABCC10 and ABCC11 associates with survival of colorectal cancer patients. Cancer Chemotherapy and Pharmacology, 78, 2016:595-603. DOI: 10.1007/s00280-016-3114-7

2015

1. Karlikova M., Topolcan O., Wolfe O., Barak V., Zima T.: Optimal Use of Biomarkers in Oncology. BioMed Research International, neuveden, 2015:nestránkováno. DOI: 10.1155/2015/423159
2. Travnicek I., Branzovsky J., Kalusova K., Hes O., Holubec L., Bauleth PKD., Ürge T., Hora M.: Tissue Biomarkers in Predicting Response to Sunitinib Treatment of Metastatic Renal Cell Carcinoma. Anticancer Research, 35, 2015:5661-5666.
3. Fiala O., Pesek M., Finek J., Minarik M., Benesova L., Bortlicek Z., Topolcan O.: Statins augment efficacy of EGFR-TKIs in patients with advanced-stage non-small cell lung cancer harbouring KRAS mutation. Tumor Biology, 36, 2015:5801-5805. DOI: 10.1007/s13277-015-3249-x
4. Fiala O., Finek J., Büchler T., Matejka VM., Holubec L., Kulhankova J., Bortlicek Z., Liska V., Topolcan O.: The Association of Serum Carcinoembryonic Antigen, Carbohydrate Antigen 19-9, Thymidine Kinase, and Tissue Polypeptide Specific Antigen with Outcomes of Patients with Metastatic Colorectal Cancer Treated with Bevacizumab: a Retrospective Study. Targeted Oncology, 10, 2015:549-555. DOI: 10.1007/s11523-015-0365-x
5. Fiala O., Pesek M., Finek J., Topolcan O., Racek J., Minarik M., Benesova L., Bortlicek Z., Poprach A., Büchler T.: High serum level of C-reactive protein is associated with worse outcome of patients with advanced-stage NSCLC treated with erlotinib. Tumor Biology, 36, 2015:9215-9222. DOI: 10.1007/s13277-015-3660-3
6. Vodicka P., Musak Ľ., Frank C., Kazimirova A., Vymetalkova V., Barancokova M., Smolkova B., Dzupinkova Z., Jiraskova K., Vodenkova S., Kroupa M., Osina O., Naccarati A., Palitti F., Försti A., Dusinska M., Vodickova L., Hemminki K.: Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects. Carcinogenesis, 36, 2015:1299-1306. DOI: 10.1093/carcin/bgv127
7. Slyskova J., Cordero F., Pardini B., Korenkova V., Vymetalkova V., Bielik Ľ., Vodickova L., Pitule P., Liska V., Matejka V., Levy M., Büchler T., Kubista M., Naccarati A., Vodicka P.: Post-treatment recovery of suboptimal DNA repair capacity and gene expression levels in colorectal cancer patients. Molecular Carcinogenesis, 54, 2015:769-778. DOI: 10.1002/mc.22141
8. Hayes M., Peckova K., Martinek P., Hora M., Kalusova K., Straka L., Daum O., Kokoskova B., Rotterova P., Pivovarcikova K., Branzovsky J., Dubova M., Vesela P., Michal M., Hes O.: Molecular-genetic analysis is essential for accurate classification of renal carcinoma resembling Xp11.2 translocation carcinoma. Virchows Archiv : an international journal of pathology, 466, 2015:313-322. DOI: 10.1007/s00428-014-1702-7
9. Bruha J., Vycital O., Tonar Z., Mirka H., Haidingerova L., Benes J., Palek R., Skala M., Treska V., Liska V.: Monoclonal Antibody Against Transforming Growth Factor Beta 1 Does Not Influence Liver Regeneration After Resection in Large Animal Experiments. In Vivo, 29, 2015:327-340.
10. Mirka H., Korcakova E., Kastner J., Hora M., Hes O., Hosek P., Ferda J.: Diffusion-weighted Imaging Using 3.0 T MRI as a Possible Biomarker of Renal Tumors. Anticancer Research, 35, 2015:2351-2357.
11. Ferda J., Ferdova E., Baxa J., Kreuzberg B., Daum O., Treska V., Skalicky T.: The Role of 18F-FDG Accumulation and Arterial Enhancement as Biomarkers in the Assessment of Typing, Grading and Staging of Hepatocellular Carcinoma Using 18F-FDG-PET/CT with Integrated Dual-phase CT Angiography. Anticancer Research, 35, 2015:2241-2246.
12. Karlikova M., Polivka J., Strojil J., Topolcan O.: A road toward better education in personalized medicine at universities and beyond. Personalized Medicine, 12, 2015:259-267. DOI: 10.2217/pme.14.84
13. Tonar Z., Kubikova T., Prior C., Demjen E., Liska V., Kralickova M., Witter K.: Segmental and age differences in the elastin network, collagen, and smooth muscle phenotype in the tunica media of the porcine aorta. Annals of Anatomy, 201, 2015:79-90. DOI: 10.1016/j.aanat.2015.05.005
14. Vodenkova S., Polivkova Z., Musak Ľ., Smerhovsky Z., Zoubkova H., Sytarova S., Kavcova E., Halasova E., Vodickova L., Jiraskova K., Svoboda M., Ambrus M., Hemminki K., Vodicka P.: Structural chromosomal aberrations as potential risk markers in incident cancer patients. Mutagenesis, 30, 2015:557-563. DOI: 10.1093/mutage/gev018
15. Peckova K., Martinek P., Ohe C., Kuroda N., Bulimbasic S., Mundo EC., Montiel DP., Lopez JI., Daum O., Rotterova P., Kokoskova B., Dubova M., Pivovarcikova K., Bauleth P., Grossmann P., Hora M., Kalusova K., Davidson W., Slouka D., Sulc M., Buzrla P., Mirka H., Michal M., Hes O.: Chromophobe renal cell carcinoma with neuroendocrine and neuroendocrine-like features. Morphologic, immunohistochemical, ultrastructural, and array comparative genomic hybridization analysis of 18 cases and review of the literature. Annals of Diagnostic Pathology, 19, 2015:261-268. DOI: 10.1016/j.anndiagpath.2015.05.001

Books and chapters in books

2016

• Liska V. – editor: Experimental surgery. Nava, Plzen, 2016. ISBN 978-80-7211-490-0. Liska V., Treska V., Novak P., Vycital O., Bruha J., Palek R., Rosendorf J.: Importance of complications of colorectal anastomosis on oncologic results. In: Koloproktologie vybrané kapitoly. Editors: Hoch J., Antos F. Mlada fronta, Praha, 2016, ISBN: 978-80-204-4179-9