The Chaperon project and STRATAGEM COST Action invite you to a lecture on 22nd February 2022, at 1:30 – 2:45 p.m. (Blue Lecture Hall, UniMeC, Faculty of Medicine in Pilsen, alej Svobody 76, Plzeň).
Familial occurrence of oropharyngeal and other HPV-associated cancers (OPC)
Prof. Kari Hemminki (European Research Area Chair of Translational Oncology) will provide presentation associate with investigation on Familial occurrence of oropharyngeal and other HPV-associated cancers (OPC) at section Head & Neck Forum – Epidemiology and Screening“ of the EUROGIN meeting.
CHROMOSOMAL ABERRATION IN HEALTHY PERSONS
Blood white cells of healthy individuals may contain non-recurrent, random chromosomal aberrations (CAs), which disappear with cell turnover as they provide no growth advantage. These include chromatid breaks, fragmented or missing parts of chromosomes and fusions resulting in dicentric and ring chromosomes. These nonspecific CAs have been used in monitoring of occupational populations exposed to potential carcinogenic chemicals and radiation.
T-cells as main actors in anti-tumor immunity
The long-suspected role of the importance of immunity in cancer has gained strong experimental support in the past decade. Infiltrating immune cells can function to control tumor growth or to help create an immunosuppressive environment in which the tumor can thrive. Immune surveillance by T-cells in human cancers is one of the key mechanisms of anti-cancer immunity.
Students for the following Ph.D. study topics are sought in the doctoral study programme:
Hepatocellular carcinoma (HCC) occurs in people with an underlying liver disease of either viral or toxic origin. It is usually preceded by cirrhosis. In the Czech Republic alcoholic liver disease is the major etiological factor. Tumor microenvironment is composed of myeloid (innate immunity) and lymphoid (adaptive immunity) lineages. Infiltrating immune cells can function to control tumor growth or to help create an immunosuppressive environment in which the tumor can thrive. The long suspected role for immune surveillance in human cancer has gained strong experimental support in the past decade. The concepts of ‘hot’ or ‘cold’ tumors refer to signs of inflammation (hot) when the tumor has already been infiltrated by T cells, which usually correlates with a response to immunotherapy. Even more gratifying, these scientific breakthroughs have also benefited clinical oncology in the context of diagnostics, prognostication, drug development and therapy.
For a European Union-funded project on translational cancer research, headed by Professor Kari Hemminki, several postdoctoral positions with different areas of expertize are currently sought to work in Biomedical Center, Faculty of Medicine, Charles University in Pilsen, Czech Republic.
The focus will be initially on colorectal cancer. The aims are to assess genetic and cellular changes taking place in the progression of colorectal cancer from precursor tumors (adenomas) to single or multiple colorectal cancers and lastly to metastases. The results will help to understand the role of genetic and cellular events at different phases of tumor development with possible clues about therapeutic targets. While the evidence shows that majority of colorectal carcinomas evolve from adenomatous polyps it is also believed that most neoplastic adenomas may not evolve to cancer. Immune system plays a key role in trying to suppress malignant transformation. Under the pressure of immune surveillance, surviving tumor cells tend to selectively accumulate traits that help them evade immune destruction.
Biomedical Center, Faculty of Medicine in Pilsen, Charles University, is seeking students for the following Ph.D. study topics in the doctoral study programme of Experimental Surgery:
