Novel model of liver microperfusion

Understanding of liver parenchyma regeneration, which a long-term research topic of the Laboratory of Cancer Treatment and Tissue Regeneration, is crucial for further development of hepatic surgery.

In our collaboration with the Department of Mechanics of the Faculty of Applies Sciences, University of West Bohemia, we address this issue using mathematical modelling of liver perfusion with respect to hepatic microanatomy. As one of the results of this effort, a new periodic microanatomical unit – liver representative periodic cell – has been proposed as an alternative to the classical representation originating from the histological structure of the liver. The design of this new unit is based on the geometric characteristics of the liver lobe structure in relation to a multiscale perfusion model derived using the theory of porous media with so-called ‘dual porosity’, which represents the capillary vasculature. The team led by prof. Ing. Eduard Rohan, DrSc., have recently published this result in a Q1 journal PLoS One. The publication was supported by the joint project of the University of West Bohemia and the Faculty of Medicine in Pilsen, Charles University, called AMTMI: Application of Modern Technologies in Medicine and Industry CZ.02.1.01/0.0/0.0/17_048/0007280.

Rohan E., Camprová-Turjanicová J., Liška V.: Geometrical model of lobular structure and its importance for the liver perfusion analysis, PLoS One. 2021 Dec 2;16(12):e0260068. doi: 10.1371/journal.pone.0260068.

Prof. MUDr. Václav Liška, Ph.D.

Contact

Charles University
Faculty of Medicine in Pilsen
Biomedical Center

alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí

T: +420 377 593 810
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