Publication of the Laboratory of Pharmacogenomics and the Laboratory of Cancer Treatment "Non-coding RNAs as Biomarkers of Tumor Progression and Metastatic Spread in Epithelial Ovarian Cancer"

Members of the Laboratory of Pharmacogenomics (K. Šeborová, P. Souček and R. Václavíková) and the Laboratory of Cancer Treatment and Tissue Regeneration (P. Vodička) in cooperation with prof. L. Rob from the University Hospital Kralovske Vinohrady recently published a review article in Cancers (IF 6.1, Q1 in Oncology).

This review article summarizes the complex role of non-coding RNAs in the progression of ovarian cancer. In detail, the article focuses on the role of microRNA (miRNA) and long non-coding RNA (lncRNA) in epithelial-mesenchymal transition in ovarian cancer as a major process behind the development of metastases. It also describes an important relationship between miRNA/lncRNA and DNA methylation. Detail knowledge of complex interaction networks between protein-coding genes, non-coding RNAs and DNA methylation may lead to the identification of potential biomarkers for the early detection of possible cancer progression.

Link here.

Šeborová et all

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