Quantitative evaluation of decellularized liver scaffold quality

Last week the group of the Laboratory of Cancer Treatment and Tissue Regeneration published a paper focusing on research related to preparation of scaffolds for liver tissue engineering purposes in the Journal of Tissue Engineering (Q2, IF = 4.1).

Research article “Novel morphological multi-scale evaluation system for quality assessment of decellularized liver scaffolds” addresses the lack of consistence in the scaffold quality assessment that would enable to select only the high quality scaffolds for cell repopulation experiments. Apart from conventional histological and microscopy techniques, we employed computer analysis enabling quantitative evaluation of morphological scaffold preservation. We designed a new open source software ScaffAn (Fig. 1) allowing to distinguish fine differences in scaffold quality, and thus to predict the interaction of scaffold with repopulating cells. ScaffAn can be further developed by wide scientific community for analysis of liver scaffolds from other species or even other decellularized organs. The research was lead by Dr. Vladimira Moulisova and performed in close collaboration with Prof. Uta Dahmen from the University Hospital in Jena.

Full paper is freely available on journal website: https://journals.sagepub.com/doi/full/10.1177/2041731420921121

RNDr. Vladimira Moulisova, Ph.D.

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Charles University
Faculty of Medicine in Pilsen
Biomedical Center

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