Alzheimer project launched

After many months of negotiations we've got a new transgenic rat model of Alzheimer disease called Tg F-344 AD.

This model is unique and promissing as it combines two human transgenes (for amyloid precursor protein (APPsw) and presenilin 1 (PS1ΔE9)). Introduced in 2013, they manifest age-dependent cerebral amyloidosis that precedes tauopathy, gliosis, apoptotic loss of neurons in the cerebral cortex and hippocampus, and cognitive disturbance.

Our plan is to study pathophysiology of AD onset in hippocampal and neocortical neural networks. 

The incoming animals are to set the core of a new breeding colony. Hope they did not forget how to breed...


Charles University
Faculty of Medicine in Pilsen
Biomedical Center

alej Svobody 1655/76
323 00 Plzeň – Severní Předměstí

T: +420 377 593 810
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